Official website of GRiPPA - Research Group for the Prevention of Environmental Disease - edited by Giancarlo Ugazio

Gruppo di Ricerca per la Prevenzione

della Patologia Ambientale

Research Group for the Prevention of Environmental Disease

Italiano

DYNAMICS  OF  ENVIRONMENTAL  DISEASE  THROUGHOUT  MAN'S  LIFESPAN



 

CD-4

STANDARD PROGRESSION,

PASSING THE CLINICAL HORIZON, PASSING THE POINT OF NO RETURN, NORMAL LIFE EXPECTANCY IN ITALY (76 for men, 82 for women).

POST-NATAL EXPOSURE,  FOR ALL THE LIFESPAN:

CONTENT

01

STANDARD PROGRESSION (overall picture)

02

EXPOSURE TO PATHOGENIC AGENTS

03

POSITIVITY OF BIOLOGICAL EXPOSURE INDICATORS

04

POSITIVITY OF BIOLOGICAL DAMAGE INDICATORS-> SYMPTOMS PASSING THE CLINICAL HORIZON

05

REPETITION OF EXPOSURE WORSENING OF SYMPTOMS IRREVERSIBILITY OF DAMAGE AND PASSING THE POINT OF NO RETURN DECLINE IN QUALITY OF LIFE

06

LIFE EXPECTANCY REACHED = 76 FOR MEN AND 82  FOR WOMEN (in Italy)

 

 

 

Summary

  The new-born baby generally starts life as a sort of biological adventure which is increasingly a gamble against the risks of environmental pollution a situation brought about by the parents and grandparents in their quest for so-called progress.

From the cradle, to his first steps, then on to school to learn and finally he starts to work and toil to earn his daily bread, or also to buy those much desired but non-essential consumer goods, which are a status symbol of modern and globalised societies. But along the way  he can come across environmental poisons.

In all these everyday circumstances the individual is exposed to harmful environmental agents which can enter the organism through the respiratory system, or which are taken in with food and drink. There is a compulsory transit route into which the pathogen enters at varying speed, according to the physiological conditions of the mucous membranes of the receiving organs, and generally in concentrations proportional to exposure. This is a sort of waiting room. The poison can be localised in one or more tissues which are also called target organs. This characteristic, which in technical terms is known as organotrophism, is not  an exclusive trend, but a preferential one, based especially on statistics. Actually heavy metals go everywhere, for example mercury can be found in the hair, in nails and in the brain, but it only causes damage to the nervous system. Another example can be found in lead: it goes to the kidneys, the brain, the  blood-forming bone marrow, the reproductive organs, as well as the liver, and damages all the organs except the liver. At a early stage the presence of poisons can be documented by the positivity of biological indicators.

Then the poisons can remain for a relatively long period in the tissues of primary localisation, and hence be removed and moved to another location, such as the emunctories, the sweat glands and the kidneys as preferential sites. Both in the primary location and on exiting the harmful agent can perform its toxic function, at a molecular, cellular, tissue or system level. Nature has provided these targets with defence mechanisms: their success depends on the concentration of poison, the defence capacities, as well as the duration of the harmful pathogen. When the defences are defeated, after a period of latency, at the appearance of the first symptoms, with the positivity of the biological indicators, the clinical horizon has been passed. From now on it is only possible to make early diagnosis, but no longer real prevention.

Through the case history, together with a series of diagnostic, analytical and/or instrumental tests, the physician can make an etiological diagnosis, which is very useful in environmental medicine, because it allows the patient to be removed from further exposure to the pathogen, and at the same time to receive suitable and effective treatment. In the absence of such action, the disease may become worse until it exceeds the irreversibility level. At this point the physician will have to consider replacing the tissue or the organ which does not function, or, in the case of cancer,  that sad sequence of surgical mutilation, accompanied by chemiotherapic poisoning or radiotherapic burns. From this point on, the patient has no other prospects except the possibility of a fall in his quality of life which may become so unsustainable that death may appear as a release. 

 

 

 

 

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